陶金华

发布者:潘忠芹发布时间:2023-07-27浏览次数:528

姓名陶金华     

职称高级实验师

电话051385012915

Ø 个人简介(选填)

陶金华,女,19843月生,江苏海门人,中药学专业,博士(导师:段金廒 教授 南京中医药大学副校长,国际欧亚科学院院士),现就职于ladbrokes立博体育欢迎你公共卫生院,副高(高级实验师)。

Ø 专业研究领域

目前主要从事胃肠道微生物与中药相互作用,干预炎症性肠病、慢性肾病等代谢性(慢性)疾病的功效物质基础及作用机制研究。近年来,主持国家自然科学基金 2 项(青年基金 1 项,面上项目 1 项),江苏省教育厅项目 1 项,南通市科技局项目 1 项,指导江苏省大学生创新项目2项,指导研究生创新科技项目 1 项,作为主要人员参与国家级、部省级等各级各类科研项目 10 余项。发表学术论文 30 余篇。

Ø 学术论文

近五年以第一作者/通讯作者发表的主要学术论文:

[1]Wang L, Zhu JH, Jiang XD, Ma ZX, Tao JH*. Preventive effects of the Rehmannia glutinosa Libosch and Cornus officinalis Sieb herb couple on chronic kidney disease rats via modulating the intestinal microbiota and enhancing the intestinal barrier. Front Pharmacol. 2022,8;13:942032

[2]Ling Wang, Jin-hua Tao*, Yi-fan Chen, Yu-meng Shen, Shu Jiang. Lizhong decoction ameliorates ulcerative colitis in mice via regulation of the plasma and urine metabolic profiling. Chinese Journal of Integrative Medicine, 2021.

[3]Ling Wang, Jin-hua Tao*, Min Zhao, Shu Jiang. Bioconversion pathways and metabolic profile of daidzin by human intestinal bacteria using UPLC-Q-TOF/MS. European Food Research and Technology. 2021.

[4]Jin-hua Tao, Jin-ao Duan, Wei Zhang, Shu Jiang, Jian-ming Guo, Dan-dan Wei. Polysaccharides from Chrysanthemum morifolium Ramat ameliorate colitis rats via regulation of the metabolic profiling and the NF-κB/TLR4 and IL-6 / JAK2 / STAT3 signaling pathways.  Frontiers in Pharmacology, 2018, 9: 746.

[5]Jin-hua Tao, Min Zhao, Shu Jiang, Xue-lian Pu, Xiao-yan Wei. Comparative metabolism of two major compounds in Fructus corni extracts by gut microflora from normal and chronic nephropathy rats in vitro by UPLC-Q-TOF/MS. Journal of Chromatography B, 2018, 1073: 170-176.

[6]Jin-hua Tao, Jin-ao Duan, Wei Zhang, Shu Jiang, Jian-Ming Guo. UPLC-Q-TOF/MS-based metabolic profiling comparison of four major bioactive components in normal and CKD rat plasma, urine and feces following oral administration of Cornus officinalis Sieb and Rehmannia glutinosa Libosch herb couple extract. Journal of Pharmaceutical and Biomedical Analysis, 2018, 161: 254-261.

[7]Jin-hua Tao, Jun Xu, Shu Jiang, Yong Ling, Dong-geng Wang. Simultaneous determination of the bioactive components in rat plasma by UPLC-MS/MS and application in pharmacokinetic studies after oral administration of Radix scutellariae extract. Biomedical Chromatography, 2017, 31(9): e3961.

[8]Jin-hua Tao, Shu Jiang, Jin-ao Duan, Wen-qian Qiu, Yong Ling. Polysaccharides from Chrysanthemum morifolium Ramat ameliorate TNBS-induced colitis rats by modulating the intestinal microbiota community. Oncotarget, 2017, 8(46): 80790-80803.

[9]Jin-hua Tao, Min Zhao, Yong Ling, Shu Jiang, Wen-Qian Qiu. UPLC-Q-TOF/MS-based metabolic profiles of the bioactive components in Rehmannia glutinosa Libosch and Cornus officinalis Sieb herb pair by rat intestinal bacteria. Chinese Herbal Medicines, 2017, 9(2): 147-152.

[10] Jin-hua Tao, Jin-ao Duan, Shu Jiang, Jian-ming Guo, Yi-yun Qian, Da-wei Qian. Simultaneous determination of six short-chain fatty acids in colonic contents of colitis mice after oral administration of polysaccharides from Chrysanthemum morifolium Ramat by gas chromatograph with flame ionization detector. Journal of Chromatography B, 2016, 1029-1030: 88-94.

[11] Jin-hua Tao, Jin-ao Duan, Yi-yun Qian, Da-wei Qian, Jian-ming Guo. Investigation of the interactions between Chrysanthemum morifolium flowers extract and intestinal bacteria from human and rat. Biomedical Chromatography, 2016, 30(11): 1807-1819.

[12] Jin-hua Tao, Jin-ao Duan, Shu Jiang, Yi-yun Qian, Da-wei Qian. Biotransformation and metabolic profile of buddleoside with human intestinal microflora by ultrahigh-performance liquid chromatography coupled to hybrid linear ion trap/orbitrap mass spectrometer. Journal of Chromatography B, 2016, 1025: 7-15.

[13] Jin-hua Tao, Min Zhao, Dong-geng Wang, Chi Yang, Le-yue Du, Wen-qian Qiu, Shu Jiang. Biotransformation and metabolic profile of catalpol with human intestinal microflora by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Journal of Chromatography B, 2016, 1009-1010: 163-169.

[14] Jin-hua Tao, Dong-geng Wang, Chi Yang, Jin-hua Huang, Wen-qian Qiu, Xi Zhao. Biotransformation of luteoloside by a newly isolated human intestinal bacterium using UHPLC-Q-TOF/MS. Journal of Chromatography B, 2015, 991: 1-8.

[15] Jin-hua Tao, Min Zhao, Dong-geng Wang, Chi Yang, Guang-tong Chen, Xi Zhao, Xu-lian Pu, Shu Jiang. UPLC-Q-TOF/MS-based screening and identification of two major bioactive components and their metabolites in normal and CKD rat plasma, urine and feces after oral administration of Rehmannia glutinosa Libosch extract. Journal of Chromatography B, 2015, 1001: 98-106.

Ø 主要科研项目 

近五年主持或参加的科研项目(课题):

[1]国家自然科学基金(面上项目),基于-轴的熟地黄-山茱萸配伍干预慢性肾病功效物质基础及作用机制研究(项目编号:81974518;起止时间: 2020.1-2023.12),在研,主持

[2]国家自然科学基金(青年基金),内生真菌促进苍术有效成分生物合成的信号转导及分子机制研究(项目编号:81102743;起止时间:2012.1-2014.12),已结题,主持

[3]江苏省高等学校大学生创新创业训练计划,基于代谢组学技术研究理中汤预溃疡性结肠炎的生物学机理(项目编号:202010304125Y;起止时间:2020.1-2021.12),结题, 主持指导

[4]江苏省研究生创新科研项目,基于肠道微生态/屏障系统的熟地黄-山茱萸干预 CKD 配伍机制研究 ( 项目编号: KYCX_3231 ; 起止时间: 2021.1-2022.12),结题, 主持指导

[5]江苏省高等学校大学生创新创业训练计划,基于肠道微生态探索熟地黄-山茱萸配伍干预慢性肾病的生物学机理研究(项目编号:202110304104Y;起止时间: 2021.6-2022.6),结题, 主持指导

[6]江苏省高校自然科学基金,基于肠道微生态/屏障系统的熟地黄-山茱萸干预CKD 配伍机制研究(项目编号:19KJB360019;起止时间:2019.1-2021.12),结题,主持

[7]南通市科技局项目,菊根茎叶部位多糖类物质改善炎症性肠病的生物活性及机理研究(项目编号:MS12017021-1;起止时间:2017.1-2019.12),结题, 主持

[8]江苏省大型仪器开放项目(江苏省科技资源统筹服务中心)基于肠道菌群调控肠道屏障的菊多糖菊多糖改善炎症性肠病机制研究,(项目编号:TC2021A022;起止时间:2021.9-2023.9),结题主持

[9]国家自然科学基金,基于自噬-溶酶体通路的土丁桂中潜在抗阿尔茨海默症树脂糖苷类成分的发现及其作用机制研究(项目编号:31800281;起止时间:2019.1-2022.12),结题,排名第三;

[10]国家自然科学基金,下丘脑 SIK1-CRTC1 通路在抑郁症病理过程中的作用及机制研究,(项目编号:81873795;起止时间:2019.1-2022.12),结题,排名第三;

[11]国家自然科学基金,肠道菌群稳态对阿尔兹海默症模型鼠认知和突触功能的调节机制研究(项目编号:81801080;起止时间:2019.1-2022.12),结题,排名第三;

[12]国家自然科学基金,达玛烷型三萜类成分生物转化及构效关系研究(项目编号:81102327;起止时间:2012.1-2014.12),结题,排名第三;

[13]江苏省自然科学基金,蛋白磷酸酶 1 调控 CaMKll 可变剪接在心肌缺血再灌注损伤中的作用(项目编号:BK20151276;起止时间:2016.1-2018.12),结题,排名第二。

Ø 讲授课程

《药理学》、《药物代谢动力学》、《天然药物化学》实验技术课

Ø 指导研究生情况

目前指导学术型硕士研究生3名,专业型硕士研究生1名,同等学力硕士研究生1